Magnesium concentration in plasma, leukocytes and urine of children with intermittent asthma
| Autor: | Blanka Petres, Renata Novak Mirčetić, Miljenko Raos, Slavica Dodig, Ivana Čepelak |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Adolescent Clinical Biochemistry chemistry.chemical_element Urine Biochemistry chemistry.chemical_compound Reference Values Internal medicine Blood plasma medicine Leukocytes Humans In patient Albuterol Magnesium Child Creatinine Chemistry Human organism magnesium plasma leukocytes urine intermittent asthma Biochemistry (medical) General Medicine Intermittent asthma Asthma Bronchodilator Agents Endocrinology Case-Control Studies Child Preschool Salbutamol medicine.drug |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 312(1-2) |
| ISSN: | 0009-8981 |
| Popis: | BACKGROUND: Magnesium (Mg) is involved in numerous physiological functions, including protein folding, intracellular signalling and enzyme catalysis. It acts as a smooth muscle relaxant. We decided to test changes of total Mg concentration in plasma, leukocytes and urine of 16 healthy children and 26 patients with intermittent asthma aged 3 to 14 years. METHODS: Samples were taken on the first day of broncho-obstruction and five days after the acute attack. During this period, patients were under salbutamol therapy. RESULTS: Plasma Mg concentration in patients increased by about 40% (first day 0.58+/-0.05 mmol Mg/l and five days later 0.64+/-0.04 mmol Mg/l) compared with healthy children (0.42+/-0.04 mmol Mg/l). Leukocyte Mg concentrations showed significant changes. On the first day of broncho-obstruction, Mg in leukocytes significantly decreased by about 60% (1.16+/-0.31 mmol Mg/g protein) compared to healthy children (3.04+/-0.68 mmol Mg/g protein). Five days later, Mg values significantly increased (3.28+/-1.09 mmol Mg/g protein) and almost reached the values of the healthy group. Mg concentration in urine statistically decreased by about 30% (0.55+/-0.06 mmol Mg/mmol creatinine) on the first day of broncho-obstruction compared to healthy children (0.75+/-0.05 mmol Mg/mmol creatinine). Five days after the acute attack, Mg concentration in patients' urine (0.73+/-0.07 mmol Mg/mmol creatinine) was close to values of healthy children. CONCLUSION: The results obtained indicate that the intracellular measurement of Mg concentration is relevant for estimation of magnesium concentration in the human organism. Hence, determination of Mg concentration in leukocytes may be used in evaluation of asthmatic pathology. |
| Databáze: | OpenAIRE |
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