A Rare Case of Sinonasal Lymphoepithelial Carcinoma Presented With Clinically Stage IV Disease
| Autor: | Khurram Shafique, Mark M. Gitau, Spencer Bonnerup |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Epstein-Barr Virus Infections Herpesvirus 4 Human Stage iv disease Nasal congestion Malignancy medicine.disease_cause Lymphoepithelial carcinoma 03 medical and health sciences 0302 clinical medicine Rare case medicine Humans Sinusitis In Situ Hybridization Aged business.industry Squamous Cell Carcinoma of Head and Neck 030224 pathology medicine.disease Epstein–Barr virus Dermatology Otorhinolaryngology 030220 oncology & carcinogenesis medicine.symptom business Paranasal Sinus Neoplasms |
| Zdroj: | Ear, nose,throat journal. 101(6) |
| ISSN: | 1942-7522 |
| Popis: | Sinonasal lymphoepithelial carcinoma (SLEC) is an extremely rare malignancy. We present a case of SLEC in a 77-year-old man who presented with nasal congestion and persistent sinusitis. Imaging revealed a large right nasal mass involving right paranasal sinuses along with bulky bilateral cervical lymphadenopathy. In addition, there was a fluorodeoxyglucose avid L1 vertebral lesion. Biopsy of nasal mass and cervical lymph nodes showed syncytial growth of tumor cells in a lymphoplasmacytic background. Immunohistochemical stains showed positivity for pankeratin, CK5/6, epithelial membrane antigen, p40 (focal), and p63 (focal). An Epstein-Barr virus-encoded RNA by in situ hybridization was strong and diffusely positive. Based on these pathologic findings and considering the location of tumor, diagnosis of SLEC was rendered. L1 vertebral body lesion was clinical and radiologically considered to be a metastasis. Correlation with radiology to determine the exact location of tumor is extremely important for correct diagnosis due to its histopathologic similarities with relatively more common undifferentiated type of nasopharyngeal carcinoma. No standard treatment protocol has been established for this tumor yet. To our knowledge, this is first ever report of SLEC presented with clinical stage IV disease. |
| Databáze: | OpenAIRE |
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