A systematic review and meta-analysis on the effectiveness of an invasive strategy compared to a conservative approach in patients > 65 years old with non-ST elevation acute coronary syndrome
| Autor: | Bernadette A. Tumanan-Mendoza, Louie Alfred B. Shiu, Karen V. Miralles, Noemi S. Pestaño, Rafael R Castillo, Maria Grethel C. Dimalala, Michael Joseph T. Reyes, Felix Eduardo R. Punzalan, Joan Dymphna P. Reaño |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cardiac Catheterization Cardiovascular Procedures medicine.medical_treatment Myocardial Infarction 030204 cardiovascular system & hematology Conservative Treatment Pathology and Laboratory Medicine Vascular Medicine law.invention 0302 clinical medicine Randomized controlled trial law Myocardial Revascularization Medicine and Health Sciences Coronary Heart Disease 030212 general & internal medicine Myocardial infarction Coronary Artery Bypass Non-ST Elevated Myocardial Infarction Stroke Randomized Controlled Trials as Topic Aged 80 and over education.field_of_study Coronary Artery Bypass Grafting Multidisciplinary Angina Meta-analysis Medicine Female Research Article medicine.medical_specialty Acute coronary syndrome Drug Research and Development Science Population Cardiology Surgical and Invasive Medical Procedures Hemorrhage Research and Analysis Methods 03 medical and health sciences Percutaneous Coronary Intervention Signs and Symptoms Diagnostic Medicine Internal medicine medicine Humans Clinical Trials Acute Coronary Syndrome education Aged Coronary Revascularization Pharmacology business.industry Revascularization Percutaneous coronary intervention medicine.disease Randomized Controlled Trials Relative risk Clinical Medicine business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 2, p e0229491 (2020) |
| ISSN: | 1932-6203 |
| Popis: | Background Patients 65 years old and older largely represent (>50%) hospital-admitted patients with acute coronary syndrome (ACS). Data are conflicting comparing efficacy of early routine invasive (within 48–72 hours of initial evaluation) versus conservative management of ACS in this population. Objective We aimed to determine the effectiveness of routine early invasive strategy compared to conservative treatment in reducing major adverse cardiovascular events in patients 65 years old and older with non-ST elevation (NSTE) ACS. Data sources We conducted a systematic review of randomized controlled trials (RCTs) through PubMed, Cochrane, and Google Scholar database. Study selection The studies included were RCTs that evaluated the effectiveness of invasive strategy compared to conservative treatment among patients ≥ 65 years old diagnosed with NSTEACS. Studies were included if they assessed any of the following outcomes of death, cardiovascular mortality, myocardial infarction (MI), stroke, recurrent angina, and need for revascularization. Six articles were subsequently included in the meta-analysis. Data extraction Three independent reviewers extracted the data of interest from the articles using a standardized data collection form that included study quality indicators. Disparity in assessment was adjudicated by another reviewer. Data synthesis All pooled analyses were initially done using Fixed Effects model. For pooled analyses with significant heterogeneity (I2≥ 50%), the Random Effects model was used. A total of 3,768 patients were included, 1,986 in the invasive strategy group, and 1,782 in the conservative treatment group. Results Meta-analysis showed less incidence of revascularization in the invasive (2%) over conservative treatment groups (8%), with overall risk ratio of 0.29 (95% CI 0.14 to 0.59). Across all pooled studies, no significant effect of invasive strategy on all-cause mortality, cardiovascular mortality, stroke, and MI was observed. Only one study assessed the outcome of recurrent angina. Conclusion There was a significantly lower rate of revascularization in the invasive strategy group compared to the conservative treatment group. In the reduction of all-cause mortality, cardiovascular mortality, MI, and stroke there was no significant effect of invasive strategy versus conservative treatment. This finding does not support the bias against early routine invasive intervention in patients ≥ 65 years old with NSTEACS. Further studies focusing on these patients with larger population sizes are still needed. |
| Databáze: | OpenAIRE |
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