Age Dependent Switching Role of Cyclin D1 in Breast Cancer
| Autor: | Rinaldi, Carmela, Natalia Maria, Malara, D'Angelo, Rosalia, Sidoti, Antonina, Attilio, Leotta, Santo, Lio, Basilio, Caparello, Alessia, Ruggeri, Vincenzo, Mollace, Aldo, Amato |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Aging
Cancer Research breast intra-ductal tumors cyclin D1 Breast Neoplasms Cell Cycle Proteins CCND1 Pathology and Forensic Medicine cell cycle older women Biomarkers Tumor Humans Genes Tumor Suppressor RC254-282 Aged Cell Proliferation Aged 80 and over QH573-671 Cell Cycle Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell Biology General Medicine Middle Aged Up-Regulation Cell Transformation Neoplastic Molecular Medicine Female Other Cytology |
| Zdroj: | Analytical Cellular Pathology, Vol 35, Iss 3, Pp 179-185 (2012) Analytical Cellular Pathology (Amsterdam) |
| ISSN: | 2210-7185 2210-7177 |
| Popis: | Background: Cyclin D1 gene (CCND1) plays pivotal roles in the development of several human cancers, including breast cancer, functioning as an oncogene. The aim of this study was to better understand the molecular dynamics of ductal carcinomas with regard to proliferation and the ageing process.Methods: 130 cases of ductal breast cancer in postmenopausal women, aged 52–96 in 3 age classes were selected. Tumoral tissues preserved in formaldehyde solution and subsequently embedded in paraffin were subjected to analysis Fluorescencein situHybridization (FISH), Reverse Transcription-Polymerase Chain Reaction (RT- PCR) and immuno-histochemical tests. The molecular variables studied were estimated in relation to the patients’ age.Results: The results obtained suggest that the increment of the levels of cyclin D1 in intra-ductal breast tumors in older woman that we have examined is significantly associated with a lower proliferation rate.Conclusion: Cyclin D1, which characterizes tumor in young women as molecular director involved in strengthening tumoral proliferation mechanisms, may be seen as a potential blocking molecular switch in corresponding tumours in old women. |
| Databáze: | OpenAIRE |
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