β-Adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs
| Autor: | Yukiyoshi Ajisawa, Yoshitaka Tomiyama, Kazuhiko Shinagawa, Kohichi Hayakawa, Takashi Kurita, Masuo Akahane, Young-Chol Park |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Agonist medicine.medical_specialty Procaterol medicine.drug_class Muscle Relaxation Adrenergic Rats Sprague-Dawley Catecholamines Dogs Isoprenaline Internal medicine Receptors Adrenergic beta medicine Animals Pharmacology Lagomorpha biology Chemistry Antagonist Muscle Smooth Adrenergic beta-Agonists biology.organism_classification Rats Endocrinology Bupranolol Female Dobutamine Rabbits Ureter medicine.drug |
| Zdroj: | European Journal of Pharmacology. 352:269-278 |
| ISSN: | 0014-2999 |
| Popis: | We investigated the beta-adrenoceptor subtypes mediating ureteral relaxation in rats, rabbits and dogs. The relaxing effects of beta-adrenoceptor agonists were evaluated on KCl-induced ureteral contractions. The rank order of potency of the catecholamines tested was isoprenaline > noradrenaline > adrenaline in rat ureter; isoprenaline > adrenaline > noradrenaline in rabbit ureter; only isoprenaline was effective in canine tissues. The beta1-adrenoceptor agonist, dobutamine, produced relaxation of rat ureter. The beta2-adrenoceptor agonist, procaterol, produced more significant relaxation of rabbit ureter than did dobutamine. CL-316243 [(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethylamino]propyl]-1,3-b enzodioxole-2,2-dicarboxylate] and CGP-12177A [(+/-)[4-[3[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-+ ++benzimidazol-2-one hydrochloride], beta3-adrenoceptor agonists, were more effective in relaxing canine ureter than were dobutamine and procaterol. Isoprenaline-induced relaxation was antagonized by a beta1-adrenoceptor antagonist, CGP-20712A [2-hydroxy-5(2-((2-hydroxy-3-(4-((1-methyl-4-trifluoromethyl)1H-imidazol e-2-yl)phenoxy)propyl)amino)ethoxy)-benzamide monomethane sulphonate], in rats and by a beta2-adrenoceptor antagonist, ICI-118,551 [(+/-)-1-[(2,3-dihydro-7-methyl- 1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride], in rabbits. The non-selective beta-adrenoceptor antagonist, bupranolol, antagonized isoprenaline-induced relaxation in all species tested. In conclusion, beta-adrenoceptor agonists may relax ureter by stimulating mainly beta1-adrenoceptors in rats, beta2-adrenoceptors in rabbits and mainly beta3-adrenoceptors in dogs. |
| Databáze: | OpenAIRE |
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