Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media
| Autor: | Jorma Ilonen, Olli Simell, Mikael Knip, Hanna Honkanen, Hanna Viskari, Heikki Hyöty, Elina Seppälä, Sanna Hoppu, Heini Huhtala |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty OPV Intervention group Vaccines Attenuated medicine.disease_cause Article law.invention Randomized controlled trial law Surveys and Questionnaires Viral Interference medicine Humans Children Attenuated vaccine General Veterinary General Immunology and Microbiology Respiratory tract infections business.industry Poliovirus Significant difference Public Health Environmental and Occupational Health Infant OPV oral polio vaccine OM otitis media Poliovirus Vaccines Otitis Media Infectious Diseases Otitis Daycare Vaccines Inactivated Child Preschool Molecular Medicine Female medicine.symptom IPV inactivated polio vaccine business Vaccine DIPP Diabetes Prediction and Prevention study |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| Popis: | Highlights ► We compared the amounts of otitis media episodes in OPV vs. IPV vaccinated children. ► OPV provides some protection against otitis media. ► The protective effect is strongest at the age of 6–18 months. Background The goal of this study was to evaluate whether a live attenuated poliovirus vaccine (OPV) has clinically relevant interfering effect with non-polio infections causing otitis media in young children. Methods Open trial in which the intervention group (64 children) received OPV at the age of 2, 3, 6 and 12 months. The control group (250 children) received IPV (inactivated polio vaccine) at the age of 6 and 12 months. Clinical symptoms were recorded by a questionnaire at the age of 3, 6, 12, 18 and 24 months. Results Otitis media episodes were less frequent in the OPV than in the control group. A significant difference was seen at the age of 6–18 months (IRR = 0.76 [95% CI 0.59–0.94], P = 0.011) and was particularly clear among children, who attended daycare (IRR 0.37 [95% CI 0.19–0.71], P = 0.003). Conclusions OPV provides some protection against otitis media. This effect may be mediated by viral interference with non-polio viruses. |
| Databáze: | OpenAIRE |
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