An Evaluation of Diagnostic Methods for Brucellosis -- The Value of Bone Marrow Culture
| Autor: | Eduardo Gotuzzo, Jorge Guerra, Carlos Carrillo, Lucia Llosa |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male blood and hemopoietic system Pathology medicine.medical_specialty bone marrow culture Adolescent diagnosis medicine.drug_class Antibiotics bacterium culture serology Iliac crest Brucellosis Serology Bone Marrow Agglutination Tests Internal medicine medicine Humans Immunology and Allergy human Fever of unknown origin Child purl.org/pe-repo/ocde/ford#3.03.00 [https] Aged Hematology brucella melitensis biology business.industry methodology Middle Aged medicine.disease biology.organism_classification Brucella Infectious Diseases medicine.anatomical_structure brucellosis Female Bone marrow business Brucella melitensis |
| Zdroj: | Journal of Infectious Diseases. 153:122-125 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Fifty patients, eventually diagnosed as having brucellosis, were studied prospectively for comparison of a simple culture of bone marrow aspirate from the iliac crest (0.5-1.0 ml) with two cultures of blood (5-10 ml) taken 30-60 min apart and with a tube-agglutination test. Cultures of bone marrow and blood were positive in 92% and 70% of the patients, respectively (P less than .001). Bacteria multiplied significantly faster in bone marrow cultures (4.32 vs. 6.65 days; P less than .001). All isolates were identified as Brucella melitensis biotype 1. Serological diagnosis was established in 86% of the patients. The efficacy of cultures of blood decreased significantly with chronic and subacute forms of infection, whereas that of bone marrow culture decreased only in chronic forms. Prior use of antibiotics reduced the positivity of cultures of blood but did not affect bone marrow culture. Bone marrow culture is recommended for patients with fever of unknown origin, negative serology, and unexplained articular or hematologic involvement, and patients in whom brucellosis is suspected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|