Consumption of seafood and its estimated heavy metals are associated with lipid profile and oxidative lipid damage on healthy adults from a Spanish Mediterranean area: A cross-sectional study
| Autor: | Anna Pedret, Núria Aranda, Montserrat Giralt, R. Albaladejo, Vanessa Sánchez-Martos, Ricard Solà, Alberto E. Espinel, Úrsula Catalán, Sara Fernández-Castillejo, Marco Antonio Delgado, Rosa M. Valls, Rosa Nogues, Victoria Arija, Marta Romeu |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Apolipoprotein B Mediterranean diet chemistry.chemical_element Food Contamination 030204 cardiovascular system & hematology 010501 environmental sciences 01 natural sciences Biochemistry Arsenic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Lipid oxidation Metals Heavy medicine Humans Exercise Shellfish 0105 earth and related environmental sciences General Environmental Science chemistry.chemical_classification Cadmium biology medicine.diagnostic_test Triglyceride business.industry Middle Aged Lipids Diet Oxidative Stress Cross-Sectional Studies Seafood chemistry Spain biology.protein Female Lipid profile business Water Pollutants Chemical Polyunsaturated fatty acid |
| Zdroj: | Environmental Research. 156:644-651 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2017.04.037 |
| Popis: | The association between the consumption of seafood and its benefits on cardiovascular (CVD) risk can be challenged by its heavy metal (HM) content. This study aimed to explore the association of seafood consumption and its estimated HM contents with the lipid profile and lipid oxidation biomarkers in adults from a Spanish Mediterranean area who do not present risk factors for CVD. In this cross-sectional study, the clinical history, three-day dietary record, lipid profile (LDLc, HDLc, APOB/A, and triglyceride levels), plasma oxidised LDL (oxLDL) and 8-isoprostane levels of 81 adults without risk factors for CVD [43% men, with a mean age of 43.6 years (95%CI: 40.1-47.1)] were assessed. The HM [arsenic (As), cadmium (Cd), mercury (Hg), and lead (Pb)] contents of seafood were estimated according to data from analyses of marine species in the same Mediterranean area. Moderate adherence to the Mediterranean diet (score: 4.6 of 9) with a mean seafood consumption of 74.9g/day (95%CI: 59.9-89.9), including 22.7g of shellfish per day (95%CI: 13.5-31.9), was observed. The estimated HM contents were lower than the provisional tolerable weekly intakes (PTWIs): 21.12µg/kg/week As, 0.57µg/kg/week InAs, 0.15µg/kg/week Cd, 1.11µg/kg/week Hg and 0.28µg/kg/week Pb. After adjusting by confounder variables, an increase in shellfish consumption was associated with increases in the levels of LDLc (P=0.013), non-HDLc (P=0.015), APOB/A (P=0.02) and plasma oxLDL (P=0.002). Moreover, an increase in the estimated As and Hg levels in shellfish was associated with an increase in LDLc (P=0.015 and P=0.018, respectively), non-HDLc (P |
| Databáze: | OpenAIRE |
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