Characterisation and outcomes of patients referred to a regional cancer of unknown primary team: a 10-year analysis
| Autor: | Marjory MacLennan, Karin Purshouse, Sally Clive, Mark Stares, C. Barrie, Rachel Haigh, Rebekah Patton, Aoife Gatenby, Jo McGinty, Jenny Irvine, Alan Christie, Gillian Knowles |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors MEDLINE Article Secondary care Cancer of unknown primary Regional cancer medicine Humans Prospective Studies Pathological Aged business.industry General surgery Cancer medicine.disease Treatment Outcome Oncology Unknown primary Neoplasms Unknown Primary Female business Median survival |
| Zdroj: | British Journal of Cancer Stares, M, Purshouse, K, Knowles, G, Haigh, R, Irvine, J, Gatenby, A, Patton, R, Mcginty, J, Christie, A, Maclennan, M, Barrie, C & Clive, S 2021, ' Characterisation and outcomes of patients referred to a regional cancer of unknown primary team: a 10-year analysis ', British Journal of Cancer . https://doi.org/10.1038/s41416-021-01544-1 |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/s41416-021-01544-1 |
| Popis: | Background In the United Kingdom, national guidance published in 2010 recommended the establishment of specialist teams to improve clinical pathways for patients presenting with malignancies of undefined primary origin (MUO) and cancer of unknown primary (CUP). This study sought to define outcomes of patients referred to a regional MUO/CUP service. Methods Data were collected prospectively on all patients (n = 1225) referred to a regional CUP team over a 10-year period. Patient demographics, clinical, pathological and outcome data were recorded and analysed. Results Confirmed CUP (cCUP) was diagnosed in 25% of patients. A primary metastatic cancer was identified in 36%, 5% were diagnosed with provisional CUP (pCUP), 27% retained the diagnosis of MUO and in 8% a non-cancer diagnosis was made. Median survival was low in all patients with a final malignant diagnosis: primary identified 9.0 months, cCUP 4.0 months, pCUP 1.5 months and MUO 1.5 months. Conclusions Patients presenting with MUO have poor outcomes irrespective of the final diagnosis. These patients need a patient-centred, streamlined, rapid diagnostic pathway. There are clear benefits to primary and secondary care teams having access to a dedicated, multidisciplinary MUO/CUP service, with clinical nurse specialists supporting the patients, to help facilitate this pathway and ensure early oncology review. |
| Databáze: | OpenAIRE |
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