Triazolam protein binding and correlation with alpha-1 acid glycoprotein concentration
| Autor: | Randy P. Juhl, Randall B. Smith, Patricia D. Kroboth, Michael I. Sorkin, Michael Garry, Marcia R. Silver, Raymond Rault |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Triazolam Adolescent Orosomucoid Plasma protein binding Peritoneal Dialysis Continuous Ambulatory Pharmacokinetics Renal Dialysis Albumins medicine Humans Pharmacology (medical) Equilibrium dialysis Carbon Radioisotopes Aged Pharmacology chemistry.chemical_classification Chromatography biology Albumin Metabolism Middle Aged Anti-Anxiety Agents chemistry biology.protein Glycoprotein Protein Binding medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 36:379-383 |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | On two occasions separated by a minimum of 1 wk, plasma was obtained from 12 patients (aged 18 to 73 yr) on dialysis after an overnight fast. Samples were assayed for albumin and α1-acid glycoprotein (AGP) concentrations. 14C-Triazolam was added to each sample to a final concentration of 5 ng/ml. Protein binding was determined by equilibrium dialysis. Unbound triazolam ranged from 6.4% to 15.4% (X = 10.0%). AGP concentrations ranged from 71.8 to 205.1 mg% (X = 123.4 mg%). Triazolam binding ratio (bound/unbound concentration) correlated with AGP concentration (r2 = 0.69) but not with albumin concentration, age, or sex. This correlation was verified by adding AGP in varying amounts to control plasma. Clinical Pharmacology and Therapeutics (1984) 36, 379–383; doi:10.1038/clpt.1984.191 |
| Databáze: | OpenAIRE |
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