Intratympanic gentamicin treatment of patients with Ménière's disease with normal hearing
| Autor: | Julie Daugherty, Jack J. Wazen, Mark J. Van Ess, Yadiel A. Alameda, Herbert Silverstein |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Tympanic Membrane Intratympanic gentamicin Audiometry Hearing Vertigo Caloric Tests otorhinolaryngologic diseases medicine Humans In patient Stage (cooking) Meniere Disease Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test biology business.industry Electronystagmography Retrospective cohort study Middle Aged medicine.disease biology.organism_classification Surgery Treatment Outcome Otorhinolaryngology Speech Perception Audiometry Pure-Tone Female Gentamicins business Meniere's disease |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 142:570-575 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | Understand the safety and outcomes of intratympanic gentamicin treatment in patients with Ménière's disease with normal hearing.Case series with chart review.Tertiary referral center.A total of 224 patients with disabling Ménière's disease treated between May 1996 and June 2007 were grouped according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) 1995 Committee on Hearing and Equilibrium staging guidelines: stage 1 (25 dB pure-tone average [PTA]); stage 2 through 4 (25 dB PTA). Patients underwent self-treatment with intratympanic gentamicin (10 mg/mL) three times daily for one to eight weeks. Outcome measures included pre- and post-treatment speech discrimination score (SDS), PTA, electronystagmography, vertigo relief, and statistical analysis utilizing the Pearson chi(2) test.Twenty-two (88%) of 24 patients with stage 1 Ménière's disease showed unchanged or improved SDS. All 24 patients showed a mean PTA loss of 8 dB. Seventeen (71%) patients reported complete or improved vertigo control. One hundred sixteen (59%) of 200 patients with stage 2 through 4 Ménière's disease showed unchanged or improved SDS. All 200 patients showed a mean PTA loss of 11 dB. One hundred forty-eight (74%) patients reported complete or improved vertigo control.Patients with stage 1 Ménière's disease appear to have similar vertigo control with better hearing preservation than patients with advanced disease when treated with low-dose intratympanic gentamicin (10 mg/mL). |
| Databáze: | OpenAIRE |
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