Photo-Fenton and Fenton-like processes for the treatment of the antineoplastic drug 5-fluorouracil under simulated solar radiation
| Autor: | Eleni Evgenidou, Α. Koltsakidou, M. Sykiotou, Ioannis Konstantinou, Maria Antonopoulou, Dimitra A. Lambropoulou |
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| Rok vydání: | 2016 |
| Předmět: |
inorganic chemicals
Light Health Toxicology and Mutagenesis Antineoplastic drug Antineoplastic Agents 02 engineering and technology 010501 environmental sciences Radiation 01 natural sciences Mineralization (biology) medicine Environmental Chemistry 0105 earth and related environmental sciences Low toxicity Chemistry Environmental engineering General Medicine Hydrogen Peroxide 021001 nanoscience & nanotechnology Pollution Fluorouracil Toxicity Photocatalysis Degradation (geology) 0210 nano-technology Nuclear chemistry medicine.drug |
| Zdroj: | Environmental science and pollution research international. 24(5) |
| ISSN: | 1614-7499 |
| Popis: | In the present study, photo-Fenton and Fenton-like processes were investigated for the degradation and mineralization of the antineoplastic drug 5-fluorouracil (5-FU). For the optimization of photo-Fenton treatment under simulated solar light (SSL) radiation, the effects of several operating parameters (i.e., 5-FU concentration, Fe3+, and oxidant concentration) on the treatment efficiency were studied. According to the results, SSL/[Fe(C2Ο4)3]3-/Η2Ο2 process was the most efficient, since faster degradation of 5-FU and higher mineralization percentages were achieved. All the applied processes followed quite similar transformation routes which include defluorination-hydroxylation as well as pyrimidine ring opening, as demonstrated by the transformation products identified by high resolution mass spectrometry analysis. The toxicity of the treated solutions was evaluated using the Microtox assay. In general, low toxicity was recorded for the initial solution and the solution at the end of the photocatalytic treatment, while an increase in the overall toxicity was observed only at the first stages of SSL/Fe3+/Η2Ο2 and SSL/Fe3+/S2O82- processes. |
| Databáze: | OpenAIRE |
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