Jejunal atresia related to the use of methylene blue in genetic amniocentesis in twins
| Autor: | Hans Wolf, J. G. Van der Pol, N. J. Leschot, P.E. Treffers, H. A. Hey, A. Vos, Kees Boer |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Amniotic fluid Twins Amniotic sac Prenatal diagnosis Injections Pregnancy medicine Humans Amnion Twin Pregnancy Netherlands Retrospective Studies medicine.diagnostic_test Obstetrics business.industry Incidence (epidemiology) Incidence Infant Newborn Obstetrics and Gynecology medicine.disease Surgery Methylene Blue medicine.anatomical_structure Jejunum In utero Atresia Pregnancy Trimester Second Amniocentesis Female business |
| Zdroj: | British journal of obstetrics and gynaecology, 99(2), 141-143. Wiley-Blackwell Europe PubMed Central |
| ISSN: | 0306-5456 |
| Popis: | Objective To calculate the incidence of jenunal atresia in newborns in The Netherlands. To study the relation between the occurrence of jejunal atresia and genetic amniocentesis to determine a possible iatrogenic cause for the unexpected high incidence of this anomaly in twins. Design Retrospective study. Subjects Eighty-nine consecutive twin pregnancies in which amniocentesis had been performed for prenatal diagnosis. In 86 methylene blue solution had been used to mark the amniotic cavity that was punctured first. Main outcome measure The occurrence of jejunal atresia in one of the two twin infants. Results The incidence of jejunal atresia at birth in The Netherlands is estimated to be 1 in 14 000. This anomaly occurred in 17 out of 89 twin pregnancies (19%). In 15 of the 17 it was possible to determine which of the two children had been exposed to intra-amniotic methylene blue. In all 15 pregnancies, the infant exposed to the dye was suffering from jejunal atresia. Conclusion A causal relation between the use of methylene blue in second trimester amniocentesis and the occurrence of jejunal atresia is strongly suggested. We recommend that no dyes should be injected into the amniotic sac. |
| Databáze: | OpenAIRE |
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