Fate of the analgesic and anti-inflammatory drug K 4277 after oral administration to man
| Autor: | V. Tamassia, L. M. Fuccella, G Valzelli, E. Moro, G. C. Goldaniga, G. P. Tosolini |
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| Rok vydání: | 1973 |
| Předmět: |
Adult
Male Drug Chromatography Gas Indoles medicine.drug_class media_common.quotation_subject Analgesic Anti-Inflammatory Agents Glucuronates Urine Pharmacology Kidney Anti-inflammatory Oral administration medicine Humans Pharmacology (medical) Carbon Radioisotopes media_common Analgesics Phenylpropionates Chemistry General Medicine Metabolism Middle Aged Blood proteins Kinetics Intestinal Absorption Chromatography Thin Layer Glucuronide Protein Binding |
| Zdroj: | European Journal of Clinical Pharmacology. 6:256-260 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00644742 |
| Popis: | The fate of the new analgesic and anti-inflammatory agent α-[4-(1-oxo-2-iso-indolinyl)-phenyl]-propionic acid (compound K 4277) in healthy volunteers has been investigated by a radio-isotope method and gas-liquid chromatography. After oral administration, the drug was absorbed rapidly and completely and occurred in plasma mainly as unchanged compound bound extensively to plasma proteins. Its disappearance from plasma followed at least a bi-exponential function and was almost complete in 24 to 48 h. Most of the drug is excreted in urine as a glucuronide and a lesser amount as the unchanged compound. There were only negligible amounts of other metabolites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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