Tyrosine kinase signaling pathways in neutrophils
Autor: | Krisztina Futosi, Attila Mócsai |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Integrins Chemokine Neutrophils Immunology Integrin Syk Inflammation Receptors Fc Protein tyrosine phosphatase Neutrophil Activation Receptor tyrosine kinase 03 medical and health sciences medicine Animals Humans Immunology and Allergy biology Protein-Tyrosine Kinases Immunity Innate 3. Good health Cell biology Receptors Antigen 030104 developmental biology Selectins biology.protein Chemokines medicine.symptom Signal transduction Tyrosine kinase Signal Transduction |
Zdroj: | Immunological Reviews. 273:121-139 |
ISSN: | 0105-2896 |
DOI: | 10.1111/imr.12455 |
Popis: | Neutrophils play a critical role in antimicrobial host defense, but their improper activation also contributes to inflammation-induced tissue damage. Therefore, understanding neutrophil biology is important for the understanding, diagnosis, and therapy of both infectious and inflammatory diseases. Neutrophils express a large number of cell-surface receptors that sense extracellular cues and trigger various functional responses through complex intracellular signaling pathways. During the last several years, we and others have shown that tyrosine kinases play a critical role in those processes. In particular, Src-family and Syk tyrosine kinases couple Fc-receptors and adhesion receptors (integrins and selectins) to various neutrophil effector functions. This pathway shows surprising similarity to lymphocyte antigen receptor signaling and involves various other enzymes (e.g. PLCγ2), exchange factors (e.g. Vav-family members) and adapter proteins (such as ITAM-containing adapters, SLP-76, and CARD9). Those mediators trigger various antimicrobial functions and play a critical role in coordinating the inflammatory response through the release of inflammatory mediators, such as chemokines and LTB4 . Interestingly, however, tyrosine kinases have a limited direct role in the migration of neutrophils to the site of inflammation. Here, we review the role of tyrosine kinase signaling pathways in neutrophils and how those pathways contribute to neutrophil activation in health and disease. |
Databáze: | OpenAIRE |
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