Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism
| Autor: | V. G. Abushkevich, Yu. V. Kashina, O. V. Gumerova, N. V. Zabolotskikh, V. M. Pokrovskii, A. G. Penzhoyan, V. Yu. Gorbunova, O. V. Kiek |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Serotonin Adolescent Genotype Tryptophan Hydroxylase Biology Serotonergic Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Young Adult 03 medical and health sciences 0302 clinical medicine Gene Frequency Pulmonary Heart Disease Polymorphism (computer science) Receptor Serotonin 5-HT2C Humans Genetic Predisposition to Disease Receptor Serotonin 5-HT2A Gene 5-HT receptor Genetics Neurotransmitter Agents TPH1 TPH2 General Medicine Tryptophan hydroxylase 030104 developmental biology Gene polymorphism 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:487-488 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The regulatory and adaptive status was determined in 202 healthy subjects by the parameters of the cardiorespiratory synchronism probe. We performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase TPH1 (A218C polymorphism) and TPH2 (G703T polymorphism), and serotonin receptors (HTR2C and HTR2A genes). The association of the regulatory and adaptive status of a subject with the polymorphism of serotonergic mediator system genes was revealed. |
| Databáze: | OpenAIRE |
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