[18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia
| Autor: | Duk L. Na, Seongho Seo, Yeong Bae Lee, Tatsuo Ido, Sung Ho Woo, Shozo Furumoto, Kazuhiko Yanai, Nobuyuki Okamura, Hyon Lee, Sang-Yoon Lee, Jae Hyeok Heo, Kee Hyung Park, Cindy W. Yoon, Young Noh, Jae Myeong Kang, Hye Jin Jeong, Jaelim Cho, Kyoung Min Lee, Victor L. Villemagne |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Aminopyridines Amyloid pet tau Proteins 030218 nuclear medicine & medical imaging Primary progressive aphasia 03 medical and health sciences 0302 clinical medicine Text mining Humans Medicine In patient Aged medicine.diagnostic_test business.industry Neuropsychology Brain Magnetic resonance imaging Pet imaging medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Aphasia Primary Progressive Positron emission tomography Positron-Emission Tomography Quinolines Female Radiopharmaceuticals Geriatrics and Gerontology business Nuclear medicine Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer Disease & Associated Disorders. 32:62-69 |
| ISSN: | 0893-0341 |
| DOI: | 10.1097/wad.0000000000000216 |
| Popis: | BACKGROUND Semantic variant primary progressive aphasia (svPPA) has been associated with a variety of proteinopathies, mainly transactive response DNA-binding protein, but also with tau and β-amyloid. Recently selective tau tracers for positron emission tomography (PET) have been developed to determine the presence of cerebral tau deposits in vivo. Here, we investigated the topographical distribution of THK5351 in svPPA patients. MATERIALS AND METHODS Five svPPA patients, 14 Alzheimer's disease patients, and 15 age-matched normal controls underwent [F]-THK5351 PET scans, magnetic resonance imaging, and detailed neuropsychological tests. [F]-fluorodeoxyglucose PET was obtained in 3 svPPA patients, whereas the remaining 2 underwent amyloid PET using [F]-flutemetamol. Tau distribution among the 3 groups was compared using regions of interest-based and voxel-based statistical analyses. RESULTS In svPPA patients, [F]-THK5351 retention was elevated in the anteroinferior and lateral temporal cortices compared with the normal controls group (left>right), and in the left inferior and temporal polar region compared with Alzheimer's disease patients. [F]-THK5351 retention inversely correlated with glucose metabolism, whereas regional THK retention correlated with clinical severity. [F]-flutemetamol scans were negative for β-amyloid. CONCLUSIONS These findings show that [F]-THK5351 retention may be detected in cortical regions correlating with svPPA pathology. |
| Databáze: | OpenAIRE |
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