Treatment of unconjugated jaundice with dicophane
| Autor: | Jason L. Robinson, Stathers Gm, Richard P. H. Thompson, A.E.M McLean, Roger Williams, C.W.T. Pilcher |
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| Rok vydání: | 1969 |
| Předmět: |
Drug
Liver Cirrhosis Male medicine.medical_specialty Adolescent media_common.quotation_subject Glucuronates Gastroenterology DDT Hyperbilirubinemia Hereditary Transferases Internal medicine medicine Animals Humans media_common business.industry Proteins Bilirubin General Medicine Organ Size Jaundice Endocrinology Liver Enzyme Induction Phenobarbital Cytochromes medicine.symptom business Protein Binding |
| Zdroj: | Lancet (London, England). 2(7610) |
| ISSN: | 0140-6736 |
| Popis: | Oral dicophane rapidly reduced the plasma-bilirubin of a boy with familial, unconjugated non-haemolytic jaundice, who had previously shown a response to phenobarbitone. For the seven months since treatment with dicophane was stopped his plasma-bilirubin level has remained low. This is attributable to slow elimination of the drug from body-fat. In rats dicophane increases hepatic glucuronyl-transferase. Dicophane may be a useful treatment for certain rare types of unconjugated jaundice in which this enzyme is reduced. |
| Databáze: | OpenAIRE |
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