Use of inclusion complex of cyclodextrin with ambenonium to improve the treatment of anticholinesterase poisoning
| Autor: | M. A. Tyunin, I. M. Ivanov, A. S. Nikiforov, M. A. Yudin, T. M. Kornyukhina |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Erythrocytes Beta-Cyclodextrins Pharmacology Blood–brain barrier General Biochemistry Genetics and Molecular Biology Ambenonium chemistry.chemical_compound medicine Animals Cholinesterase chemistry.chemical_classification biology Cyclodextrin Chemistry beta-Cyclodextrins Brain General Medicine Acetylcholinesterase Ambenonium Chloride Rats Drug Combinations Anticholinesterase poisoning medicine.anatomical_structure biology.protein Ambenonium chloride Cholinesterase Inhibitors medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 155(2) |
| ISSN: | 1573-8221 |
| Popis: | The complex of ambenonium with methyl-β-cyclodextrin injected intramuscularly to rats caused more pronounced inhibition of acetylcholinesterase in erythrocyte and brain than free drug. The use of this complex as part of combined therapy significantly reduces mortality in animals during experimental anticholinesterase poisoning in comparison with the controls. |
| Databáze: | OpenAIRE |
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