A nanostructured anti-biofilm surface widens the efficacy against spindle-shaped and chain-forming rod-like bacteria
| Autor: | Zhiyong Fan, Xiao-Zhuang Jin, Yao Min Zhu, Gary S.P. Cheung, David W Green, Xin Li, Kwong Hoi Tsui, Xu Guang Li, James K.H. Tsoi, Yong Qiang Deng |
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| Rok vydání: | 2020 |
| Předmět: |
Antimicrobial peptides
02 engineering and technology medicine.disease_cause Streptococcus mutans 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents medicine General Materials Science Nanotopography biology Chemistry Biofilm Biomaterial Pathogenic bacteria 030206 dentistry 021001 nanoscience & nanotechnology biology.organism_classification Anti-Bacterial Agents Biofilms Biophysics Surface modification Antimicrobial surface 0210 nano-technology Porphyromonas gingivalis Bacteria |
| Zdroj: | Nanoscale. 12:18864-18874 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/d0nr03809a |
| Popis: | Current control of pathogenic bacteria at all biomaterial interfaces is poorly attuned to a broad range of disease-causing pathogens. Leading antimicrobial surface functionalization strategies with antimicrobial peptides (AMPs), defensins, have not shown their promised efficacy. One of the main problems is the lack of stability and swift clearance from the surface. Surface nanotopography bearing sharp protrusions is a non-chemical solution that is intrinsically stable and long-lasting. Previously, the geometrically ordered arrays of nanotipped spines repelled or rapidly ruptured bacteria that come into contact. The killing properties so far work on cocci and rod-like bacteria, but there is no validation of the efficacy of protrusional surfaces on pathogenic bacteria with different sizes and morphologies, thus broadening the utility of such surfaces to cover increasingly more disease entities. Here, we report a synthetic analogue of nanotipped spines with a pyramidal shape that show great effectiveness on species of bacteria with strongly contrasting shapes and sizes. To highlight this phenomenon in the field of dental applications where selective bacterial control is vital to the clinical success of biomaterial functions, we modified the poly(methyl)-methacrylate (PMMA) texture and tested it against Streptococcus mutans, Enterococcus faecalis, Porphyromonas gingivalis, and Fusobacterium nucleatum. These nanopyramids performed effectively at levels well above those of normal and roughened PMMA biomaterials for dentistry and a model material for general use in medicine and disease transmission in hospital environments. |
| Databáze: | OpenAIRE |
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