A Role for MHC Class II Antigen Processing in B Cell Development
| Autor: | Susan K. Pierce, Michelle L. Dykstra, Paul C. Cheng, Tim W. Sproul |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Antigen Presentation
B-Lymphocytes Antigen processing Immunology Antigen presentation B-cell receptor Naive B cell Histocompatibility Antigens Class II Receptor editing Cell Differentiation Biology Cell biology medicine.anatomical_structure Antigen medicine Animals Humans Immunology and Allergy Antigen-presenting cell B cell |
| Zdroj: | International Reviews of Immunology. 19:139-155 |
| ISSN: | 1563-5244 0883-0185 |
| Popis: | For mature B cells, the encounter with foreign antigen results in the selective expansion of the cells and their differentiation into antibody secreting cells or memory B cells. The response of mature B cells to antigen requires not only antigen binding to and signaling through the B cell antigen receptor (BCR) but also the processing and presentation of the BCR bound antigen to helper T cells. Thus, in mature B cells, the ability to process and present antigen to helper T cells plays a critical role in determining the outcome of antigen encounter. In immature B cells, the binding of antigen results in negative selection of the B cell, inducing apoptosis, anergy or receptor editing. Negative selection of immature B cells requires antigen induced signaling through the BCR, analogous to the signaling function of the BCR in mature B cells. However, the role of class II antigen processing and presentation in immature B cells is less well understood. Current evidence indicates that the ability to process and present antigen bound to the BCR is a late acquisition of developing B cells, suggesting that during negative selection B cells may not present BCR bound antigen and interact with helper T cells. However, the expression of class II molecules is an early acquisition of B cells and recent evidence indicates that the expression of class II molecules early in development is required for the generation of long lived mature B cells. Here we review our current understanding of the processing and presentation of antigen by mature B cells and the role for antigen processing and class II expression during B cell development. |
| Databáze: | OpenAIRE |
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