Inhibitory Effects of Two Varieties of Tunisian Pomegranate (Punica granatum L.) Extracts on Gastrointestinal Transit in Rat
| Autor: | Hichem Sebai, Latifa Chehimi, Mohamed Amri, Lamjed Marzouki, Mohsen Sakly, Abdelaziz Souli, Jamel El-Benna, Kais Rtibi |
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| Rok vydání: | 2015 |
| Předmět: |
Diarrhea
Male Castor Oil Tunisia Medicine (miscellaneous) Species Specificity Animals Medicine Food science Rats Wistar Antidiarrheals Gastrointestinal Transit Medicine African Traditional Lythraceae Meal Nutrition and Dietetics biology Traditional medicine Plant Extracts business.industry Gastrointestinal transit biology.organism_classification Fruit and Vegetable Juices Fruit Punica medicine.symptom Full Communications business Phytotherapy |
| Zdroj: | Journal of Medicinal Food. 18:1007-1012 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2014.0110 |
| Popis: | The present study was undertaken to determine whether total and methanol juice extracts of two Tunisian Pomegranate (Punica granatum L.) varieties (Garsi and Gabsi) protect against diarrhea as well as their effects on gastrointestinal transit (GIT) in healthy rats. In this respect, male Wistar rats were used and divided into control- and pomegranate-treated groups. The antidiarrheal activity was evaluated using the castor oil-induced diarrhea method and the GIT was assessed using charcoal meal. Our results showed that total and methanol P. granatum juice extracts produced a significant dose-dependent protection against castor oil-induced diarrhea. Pomegranate extracts and juice also decreased the GIT significantly and dose dependently. Importantly, the Garsi variety appeared to be more effective than the Gabsi variety on these two parameters. These findings suggest that pomegranate extracts have a potent antidiarrheal property in rats confirming their efficiency in the Tunisian traditional medicine. |
| Databáze: | OpenAIRE |
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