| Autor: |
Staffan, Berg, Helena, Edlund, William, R F Goundry, Christel, A S Bergström, Nigel M, Davies |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutics. 628:122238 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/j.ijpharm.2022.122238 |
| Popis: |
This paper reviews many of the properties of a peptide that need to be considered prior to development as an oral dosage form when co-formulated with a permeation enhancer to improve oral bioavailability, including the importance and implications of peptide half-life on variability in pharmacokinetic profiles. Clinical considerations in terms of food and drug-drug interactions are also discussed. The paper further gives a brief overview how permeation enhancers overcome barriers that limit oral absorption of peptides and thereby improve their oral bioavailability, albeit bioavailabilities are still low single digit and variability is high. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect