New technique for quantitation of pituitary adenoma size: use in evaluating treatment of gonadotroph adenomas with a gonadotropin-releasing hormone antagonist
| Autor: | Mark E. Molitch, Robert I. Grossman, G A McGrath, J Rivier, Peter J. Snyder, Roberto J. Goncalves, Jayaram K. Udupa, Spyros N. Pavlou, W W Vale |
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| Rok vydání: | 1993 |
| Předmět: |
Adenoma
Adult Male endocrine system Pituitary gland medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Gonadotropin-releasing hormone Biochemistry Gonadotropin-releasing hormone antagonist Gonadotropin-Releasing Hormone Endocrinology Pituitary adenoma Internal medicine Gonadotroph adenoma Humans Medicine Pituitary Neoplasms Vision Ocular Aged medicine.diagnostic_test business.industry Biochemistry (medical) Antagonist Magnetic resonance imaging Luteinizing Hormone Middle Aged medicine.disease digestive system diseases Basophils stomatognathic diseases medicine.anatomical_structure Pituitary Gland Follicle Stimulating Hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 76:1363-1368 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.76.5.8496331 |
| Popis: | Because administration for 1 week of the GnRH antagonist Nal-Glu GnRH had been shown to decrease FSH secretion from supranormal to normal in men with gonadotroph adenomas, we investigated the effect of prolonged administration of Nal-Glu on the size of gonadotroph adenomas. To quantitate the effect of Nal-Glu GnRH on gonadotroph adenoma size, we first developed a technique for calculating adenoma volume. The technique involved collecting magnetic resonance (MR) imaging data from each adenoma at 1-mm slice intervals in the coronal, axial, and sagittal views and using the Softvu computer program to calculate adenoma volume from the MR data. The precision of this technique, as judged by the coefficients of variation of the calculations of the same view of the same study three times, was 1.7%, 1.0%, and 1.0% for each of three studies. When Nal-Glu GnRH (5 mg, sc, every 12 h) was self-administered for 3-12 months to five men with gonadotroph adenomas and supra-normal serum FSH concentrations, the serum FSH concentrations decreased to normal or below normal for the entire treatment period. Adenoma size, however, did not change during treatment in any of the five men. We conclude that calculating pituitary adenoma volume from MR data using the Softvu computer program is a highly reproducible technique, but that Nal-Glu GnRH is not an effective treatment for reducing gonadotroph adenoma size. The failure of Nal-Glu to reduce adenoma size despite its success in reducing FSH secretion suggests that FSH secretion from gonadotroph adenomas is dependent on endogenous GnRH, but growth of gonadotroph adenomas is not. |
| Databáze: | OpenAIRE |
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