Association of increased levels of omentin‐1 and carotid intima‐media thickness with early signs of cardiovascular risk in patients with polycystic ovary syndrome: A prospective case control study

Autor: Oya Gökmen, Aysegul Cebi, Şebnem Alanya Tosun, Alptekin Tosun, Murat Usta, Tuğba Gürbüz
Rok vydání: 2021
Předmět:
Zdroj: Journal of Obstetrics and Gynaecology Research. 48:169-177
ISSN: 1447-0756
1341-8076
DOI: 10.1111/jog.15077
Popis: AIM Omentin-1, an adipokine primarily secreted from visceral adipose tissue, regulates metabolic homeostasis, whereas carotid intima-media thickness (CIMT) is a valid marker for early diagnosis of atherosclerosis. We aimed to investigate whether polycystic ovary syndrome (PCOS) is related to levels of omentin-1 and CIMT and demonstrate the association with cardiovascular risk. METHODS A prospective case-control study was performed on 47 PCOS patients and 35 healthy subjects. Hormonal and metabolic parameters, levels of serum omentin-1, and CIMT were evaluated in the two groups. RESULTS The right, left, total CIMT, and levels of serum omentin-1 were significantly higher in the PCOS group than in the healthy controls (p = 0.015, p = 0.009, p = 0.021, and p = 0.002, respectively). Using multiple linear and backward elimination regression analyses, serum omentin-1 was found to be independently associated with age and Ln-transformed homeostasis model assessment of insulin resistance, and cardiovascular parameters were independently associated with body mass index (BMI). In the PCOS group, the means of right, left, and total CIMT were significantly higher in the subgroup with BMI levels ≥25 kg/m2 compared to the subgroup with BMI levels
Databáze: OpenAIRE
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