Effect of Acupuncture ‘dose— on Modulation of the Default Mode Network of the Brain
| Autor: | Chih Che Chou, David M. Niddam, Jen-Hwey Chiu, Yii Jeng Lin, Wen Jui Kuo, Tzu Chen Yeh, Chou Ming Cheng, Yen Ying Kung, Jen Chuen Hsieh |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty ACUPUNCTURE Visual Analog Scale Brain activity and meditation Rest Acupuncture Therapy Sensation Precuneus Brain mapping Transcutaneous electrical nerve stimulation law.invention Cuneus 03 medical and health sciences 0302 clinical medicine law Acupuncture Humans Medicine NEUROLOGY Default mode network Original Paper Brain Mapping Resting state fMRI business.industry Brain General Medicine Hand Magnetic Resonance Imaging 030205 complementary & alternative medicine Surgery body regions medicine.anatomical_structure Complementary and alternative medicine Needles Transcutaneous Electric Nerve Stimulation Female Neurology (clinical) Nerve Net business human activities Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Acupuncture in Medicine |
| ISSN: | 1759-9873 0964-5284 |
| DOI: | 10.1136/acupmed-2016-011071 |
| Popis: | Objective Recent functional MRI (fMRI) studies show that brain activity, including the default mode network (DMN), can be modulated by acupuncture. Conventional means to enhance the neurophysiological ‘dose’ of acupuncture, including an increased number of needles and manual needle manipulation, are expected to enhance its physiological effects. The aim of this study was to compare the effects of both methods on brain activity. Methods 58 healthy volunteers were randomly assigned into four groups that received single needle acupuncture (SNA, n=15) or transcutaneous electrical nerve stimulation (TENS, n=13) as active controls, or enhanced acupuncture by way of three needle acupuncture (TNA, n=17) or SNA plus manual stimulation (SNA+MS, n=13). Treatment-associated sensations were evaluated using a visual analogue scale. Central responses were recorded before, during, and after treatment at LI4 on the left hand using resting state fMRI. Results TNA and SNA+MS induced DMN-insula activity and extensive DMN activity compared to SNA, despite comparable levels of de qi sensation. The TNA and SNA+MS groups exhibited a delayed and enhanced modulation of the DMN, which was not observed followed SNA and TENS. Furthermore, TNA increased precuneus activity and increased the DMN-related activity of the cuneus and left insula, while SNA+MS increased activity in the right insula. Conclusions The results showed that conventional methods to enhance the acupuncture dose induce different DMN modulatory effects. TNA induces the most extensive DMN modulation, compared with other methods. Conventional methods of enhancing the acupuncture dose could potentially be applied as a means of modulating brain activity. |
| Databáze: | OpenAIRE |
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