Nucleosides 515: Synthesis of Novel 1,2,4-Triazolo[3,4-c]-1,2,4-Triazole Nucleosides

Autor:	R. Neidlein, Mosselhi A. N. Mosselhi
Rok vydání:	2009
Předmět:	Bromine Molecular Structure Hydrazine Hydrazones 1 2 4-Triazole chemistry.chemical_element Halogenation Nucleosides General Medicine Triazoles Biochemistry Acetic acid chemistry.chemical_compound chemistry Cyclization Ribose Genetics Molecular Medicine Organic chemistry Hydrate Derivative (chemistry) Acetic Acid
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 28:1095-1103
ISSN:	1532-2335 1525-7770
Popis:	Ribosylation of 3-methylthio-5-phenyl-1,2,4-triazole (1) with ribose derivative 2 gave the protected 1,2,4-triazole-nucleoside 3, which reacted with hydrazine hydrate to afford the 3-hydrazino-1,2,4-triazole derivative 5. Reaction of 5 with aromatic aldehydes yielded the corresponding hydrazones 6, which cyclized under bromination in acetic acid to give 8. Debenzoylation of 8 afforded novel 1,2,4-triazolo[3,4-c]-1,2,4-triazole nucleosides 9.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776ac664ad81f2028a57c6691de009b6 https://doi.org/10.1080/15257770903368377 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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