Mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice
| Autor: | Julia Wang, Hui Wang, Daniel T. Eitzman, Alyssa J. Lawler, Chiao Guo, Eddy B. Sun, Jintao Wang, Wei Luo, Aswin Reddy |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular smooth muscle Mouse lcsh:Medicine Apoptosis Coronary Artery Disease 030204 cardiovascular system & hematology Pharmacology Cardiovascular Microtubules Muscle Smooth Vascular Mice 0302 clinical medicine Cell Movement Molecular Cell Biology Myocyte lcsh:Science 0303 health sciences Multidisciplinary Cell migration Animal Models Hyperplasia Interventional Cardiology 3. Good health Cell Motility Mebendazole Medicine Cellular Types medicine.drug Research Article Neointima Myocytes Smooth Muscle Biophysics Biology Cell Growth 03 medical and health sciences Model Organisms In vivo Vascular Biology medicine Animals 030304 developmental biology Cell Proliferation Muscle Cells Cell growth lcsh:R Vascular System Injuries medicine.disease Disease Models Animal Immunology lcsh:Q |
| Zdroj: | PLoS ONE, Vol 9, Iss 2, p e90146 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth muscle cells, the effects of mebendazole on vascular smooth muscle cell proliferation were tested in vitro and in a mouse model of arterial injury. In vitro, mebendazole inhibited proliferation and migration of murine vascular smooth muscle cells and this was associated with altered intracellular microtubule organization. To determine in vivo effects of mebendazole following vascular injury, femoral arterial wire injury was induced in wild-type mice treated with either mebendazole or placebo control. Compared with placebo-treated mice, mebendazole-treated mice formed less neointima at the site of injury. Mebendazole is effective at inhibiting vascular smooth muscle cell proliferation and migration, and neointimal formation following arterial injury in mice. |
| Databáze: | OpenAIRE |
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