World Health Organization grade III supratentorial extraventricular ependymomas in adults: Case series and review of treatment modalities
| Autor: | Claudia Scudieri, Fotios Kalfas |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Anaplastic ependymomas Context (language use) World health 030218 nuclear medicine & medical imaging surgery 03 medical and health sciences 0302 clinical medicine Medicine Pathological Chemotherapy treatment business.industry supratentorial General Medicine extraventricular Radiation therapy Hemiparesis Treatment modality Original Article Radiology medicine.symptom business 030217 neurology & neurosurgery Pediatric population |
| Zdroj: | Asian Journal of Neurosurgery |
| ISSN: | 2248-9614 1793-5482 |
| DOI: | 10.4103/ajns.ajns_239_18 |
| Popis: | Context: Supratentorial ependymomas and their anaplastic variants are relatively uncommon central nervous system neoplasms that afflict both adults and children. Aims: Discuss the clinical and pathological features of patients with anaplastic ependymomas involving an extraventricular supratentorial location and review modalities and options of treatment for those rare tumors. Settings and Design: Whereas the treatment algorithm in the pediatric population is well established, however, treatment in the adult population is less defined. Treatment options are exposed through the author's cases and review of the literature. Subjects and Methods: In our case series of two adult patients with supratentorial ependymomas World Health Organization (WHO) Grade III (anaplastic variant), patients presented in both cases in the emergency room after having a generalized tonic–clonic seizure at home the first case, and mild hemiparesis the second case. Results: Patients underwent surgical treatment, and a gross total resection was achieved in both cases. The histopathological examination revealed a diagnosis of anaplastic ependymoma (WHO Grade III). Both patients had additional radiotherapy, and in the first case, adjuvant platinum-based chemotherapy was administered due to leptomeningeal gliomatosis. Conclusion: In our experience, gross total resection was achieved in all patients with supratentorial extraventricular ependymomas WHO Grade III with additional radiotherapy and platinum-based chemotherapy. Patients require initial close serial imaging follow-up. The role of chemotherapy is still uncertain but may be necessary in younger patients and in tumors that behave more like the pediatric ependymomas. |
| Databáze: | OpenAIRE |
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