International investigation of neurocognitive and behavioral phenotype in 47,XXY (Klinefelter syndrome): Predicting individual differences
| Autor: | Patrick Lawson, Chris Cappello, Carole A. Samango-Sprouse, Emily Stapleton, Sophie van Rijn, Leo M. J. de Sonneville, Teresa Sadeghin, Selena Chea |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Adolescent Emotions Intelligence Abnormal Karyotype CBCL Neuropsychological Tests 03 medical and health sciences 0302 clinical medicine Borderline intellectual functioning Cognition Klinefelter Syndrome Genetics medicine Humans Testosterone Child Genetics (clinical) Genetic Association Studies Netherlands Behavior Intelligence quotient Wechsler Adult Intelligence Scale Explained variation medicine.disease United States 030104 developmental biology Phenotype Female Klinefelter syndrome Psychology Neurocognitive 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | American Journal of Medical Genetics American Journal of Medical Genetics, 176(4), 877-885 |
| Popis: | 47,XXY (KS) occurs in 1:650 male births, though less than 25% are ever identified. We assessed stability of neurocognitive features across diverse populations and quantified factors mediating outcome. Forty‐four boys from the Netherlands (NL) and 54 boys from the United States (US) participated. The Wechsler Intelligence Scales assessed intellectual functioning; the ANT program evaluated cognitive function; and the CBCL assessed behavioral functioning. ANOVA was used for group comparisons. Hierarchical regressions assessed variance explained by each independent variable: parental education, timing of diagnosis, testosterone, age, and nationality. Parental education, timing of diagnosis, and hormonal treatment all played an important role in neurocognitive performance. The observed higher IQ and better attention regulation in the US group as compared to the NL group was observed with decreased levels of behavioral problems in the US group. Cognitive measures that were different between the NL and US groups, i.e., attention regulation and IQ scores, were also significantly influenced by external factors including timing of diagnosis, testosterone treatment, and parental education. On the ANT, a cognitive phenotype of 47,XXY was observed, with similar scores on 9 out of the 10 ANT subtests for the NL and US groups. This study lays additional features to the foundation for an algorithm linking external variables to outcome on various neurodevelopmental measures. |
| Databáze: | OpenAIRE |
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