PREVENTION OF POST-TRANSFUSION NON-A, NON-B HEPATITIS BY NON-SPECIFIC IMMUNOGLOBULIN IN HEART SURGERY PATIENTS
| Autor: | Manuel Leal, Juan A. Pineda, Armando Sánchez-Quijano, R. Castro, F. Garcia de Pesquera, J. Muñoz, Rivera F, M.A. Diaz-Torres, Eduardo Lissen |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Hepatitis Viral Human Post transfusion Disease Immunoglobulin E Injections Intramuscular Hepatitis Random Allocation Non specific Humans Medicine Cardiac Surgical Procedures Child Aged Hepatitis Chronic Clinical Trials as Topic biology business.industry Immunization Passive Transfusion Reaction virus diseases General Medicine Middle Aged Hepatitis B medicine.disease Hepatitis C Surgery Evaluation Studies as Topic biology.protein Non b hepatitis Female Viral disease Antibody business Follow-Up Studies |
| Zdroj: | The Lancet. 331:1245-1249 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(88)92071-5 |
| Popis: | To evaluate the effectiveness of immune serum globulin (I SG) in preventing non-A, non-B hepatitis, 291 heart surgery patients who received blood from voluntary donors were randomly assigned to receive either ISG or no additional protection. ISG was given intramuscularly before and 1 week after transfusion. 98 controls and 100 in the ISG group completed the study. Post-transfusion non-A, non-B hepatitis developed in 11 (11·2%) controls but in only 3 (3·0%) of the ISG group (p = 0·0203). 8 (727%) of control group with hepatitis had symptoms, and in 5 (45·4%) the disease became chronic. The disease was self-limiting in all 3 ISG patients affected, and only 1 of them had symptoms. Among those with non-A, non-B hepatitis aminotransferase levels were higher in the controls than in the ISG patients. Incubation periods longer than 8 weeks correlated with a tendency for the disease to become chronic. ISG recipients had shorter as well as more homogeneous incubation periods. ISG could be a safe, low-cost means for preventing post-transfusion non-A, non-B hepatitis which does not call for the discarding of donated blood. |
| Databáze: | OpenAIRE |
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