Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer

Autor: Ruth Vera, Carolina Ibarrola-de-Andrés, Jorge Adeva, Judith Pérez-Rojas, Pilar García-Alfonso, Yolanda Rodríguez-Gil, Teresa Macarulla, Teresa Serrano-Piñol, Rebeca Mondéjar, Beatriz Madrigal-Rubiales
Přispěvatelé: Institut Català de la Salut, [Vera R] Navarra University Hospital, Spanish Society of Medical Oncology (SEOM), Pamplona, Spain. [Ibarrola-de-Andrés C, Rodríguez-Gil Y] 12 de Octubre University Hospital, Spanish Society of Pathology (SEAP), Madrid, Spain. [Adeva J] 12 de Octubre University Hospital, Spanish Society of Medical Oncology (SEOM), Madrid, Spain. [Pérez-Rojas J] La Fe University and Polytechnic Hospital, Spanish Society of Pathology (SEAP), Valencia, Spain. [García-Alfonso P] Gregorio Marañón University Hospital, Spanish Society of Medical Oncology (SEOM), Madrid, Spain. [Macarulla T] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Spanish Society of Medical Oncology (SEOM), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus
Rok vydání: 2023
Předmět:
Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms [DISEASES]
Cancer Research
Consensus
Marcadors tumorals
Presa de decisions
Tracte biliar - Càncer - Diagnòstic
factores biológicos::biomarcadores::marcadores tumorales [COMPUESTOS QUÍMICOS Y DROGAS]
Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Biliary Tract Neoplasms [DISEASES]
General Medicine
Medical Oncology
Psychological Phenomena::Mental Processes::Thinking::Decision Making::Consensus [PSYCHIATRY AND PSYCHOLOGY]
Pathology and Forensic Medicine
Pancreatic Neoplasms
Biliary Tract Neoplasms
Pàncrees - Càncer - Diagnòstic
Oncology
Biomarkers
Tumor
Humans
neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias del tracto biliar [ENFERMEDADES]
Biological Factors::Biomarkers::Biomarkers
Tumor [CHEMICALS AND DRUGS]
fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión::consenso [PSIQUIATRÍA Y PSICOLOGÍA]
neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias pancreáticas [ENFERMEDADES]
Zdroj: CLINICAL & TRANSLATIONAL ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Scientia
ISSN: 1699-8855
1699-048X
Popis: Biliary tract cancer; Predictive value; Targeted therapies Cáncer de vías biliares; Valor predictivo; Terapias dirigidas Càncer de vies biliars; Valor predictiu; Teràpies dirigides Pancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment. In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours. SEOM and SEAP acknowledge the financial support for this project in the form of unrestricted collaboration in the logistics from AstraZeneca.
Databáze: OpenAIRE
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