Dose-Dependent Stimulation of Melatonin Secretion after Administration of Agnus Castus
| Autor: | C. Hildt, P. Schwinn, J. S. E. Dericks-Tan |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Dose dependence Stimulation Placebo law.invention Melatonin Endocrinology law Internal medicine Blood plasma Internal Medicine medicine Humans Circadian rhythm Melatonin secretion Plants Medicinal Dose-Response Relationship Drug Plant Extracts business.industry General Medicine Circadian Rhythm Area Under Curve Phytotherapy business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 111:44-46 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | The circadian rhythm of melatonin secretion was measured in 20 healthy males (20 - 32 yrs.) after intake of placebo or various doses of a special extract of Agnus castus (AC: 120 - 480 mg/die) for 14 days. A significant (p < 0.05) dose-dependent increase of the area under the melatonin secretion curve (AUC) was found. The pattern of circadian rhythm of melatonin secretion was, however, not influenced. It remains to be elucidated whether the AC-stimulated increase of melatonin secretion is suitable for treatment of sleep disturbances. |
| Databáze: | OpenAIRE |
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