Potential diagnostic and prognostic significance of plasma prolidase activity in gastric cancer
| Autor: | Remzi Kızıltan, Halit Demir, Eyüp Murat Yılmaz, Sebahattin Çelik, Özkan Yılmaz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Dipeptidases medicine.medical_specialty Lymphatic metastasis Clinical Biochemistry Tumor resection Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms Internal medicine Drug Discovery Biomarkers Tumor medicine Humans In patient Prospective Studies Young adult Prospective cohort study Survival rate Aged Aged 80 and over business.industry Biochemistry (medical) Case-control study Cancer Middle Aged respiratory system Prognosis medicine.disease Tumor Burden Surgery Survival Rate 030104 developmental biology ROC Curve Area Under Curve Case-Control Studies Lymphatic Metastasis 030220 oncology & carcinogenesis Female business Follow-Up Studies |
| Zdroj: | Biomarkers in Medicine. 11:319-327 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2016-0367 |
| Popis: | Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results: This study was based on a prospective design. 60 patients with gastric cancer (operable cases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidase activity was analyzed. The mean PPA levels in the operable, inoperable and control groups were 45.60 +/- 4.20, 54.35 +/- 4. 9 and 10.92 +/- 0.79 U/l, respectively (p < 0.001). PPA decreased significantly after tumor resection. PPA level was significant in differentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%). Aim: Plasma prolidase activities (PPAs) in cases of gastric cancer. Methodology/results:This study was based on a prospective design. 60 patients with gastric cancer (operablecases: 48; inoperable: 12) and 60 healthy controls were included in the study. Prolidaseactivity was analyzed. The mean PPA levels in the operable, inoperable and controlgroups were 45.60 ± 4.20, 54.35 ± 4. 9 and 10.92 ± 0.79 U/l, respectively (p < 0.001).PPA decreased significantly after tumor resection. PPA level was significant indifferentiating operable cases from inoperable (sensitivity: 91.7%; specificity: 85.2%).Discussion/conclusion: PPA was significantly higher in patients with inoperable gastriccancer than in operable cases and the control group. A strong correlation was foundbetween tumor volume and PPA. |
| Databáze: | OpenAIRE |
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