Reproductive factors, obesity and risk of colorectal cancer in a cohort of Asian women
| Autor: | Wei-Yen Lim, Thomas Shing-Hei Wong, Khuan Yew Chow, Wen Yee Chay, Min-Han Tan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Waist Epidemiology Colorectal cancer medicine.medical_treatment Cohort Studies 03 medical and health sciences 0302 clinical medicine Waist–hip ratio Asian People Risk Factors Humans Medicine Body Weights and Measures Obesity Prospective Studies 030212 general & internal medicine Reproductive History Abdominal obesity Aged Rectal Neoplasms business.industry Obstetrics Gravidity and parity Hormone replacement therapy (menopause) Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Colonic Neoplasms Cohort Female medicine.symptom Colorectal Neoplasms business Cohort study |
| Zdroj: | Cancer Epidemiology. 58:33-43 |
| ISSN: | 1877-7821 |
| Popis: | Background This study evaluated reproductive factors and obesity in relation to colorectal cancer (CRC) in Asian women. Methods The study cohort comprised 28191 women who were recruited between 1994 and 1997. During 18 years of prospective follow-up, 404 and 212 women developed colon cancer (CC) and rectal cancer (RC) respectively. Cox proportional hazards regression was used. Results Menstrual factors were not related to the risk of CRC, CC and RC. Gravidity and parity were not associated with CRC or RC, but women who were ever pregnant had a HR of 1.87 (95%CI 1.12–3.14) compared to those never pregnant, and parous women had a HR of 1.79 (95% CI 1.10–2.92) compared to nulliparous women for CC. Use of oral contraceptives and hormone replacement therapy were not associated with CRC, CC or RC. Compared to women with normal BMI, women who were obese had HRs of 1.39 (95%CI 1.12–1.74) and 1.64 (95%CI 1.24–2.16) for CRC and CC respectively. No increased risk was seen for RC. Adjusted for BMI, for colonic cancer, women in the highest quartile for Waist Circumference had a HR of 2.14 (95%CI 1.42–3.25) compared to the lowest quartile, for Waist Hip Ratio, a HR of 1.74 (95%CI 1.30–2.34), and for Waist-Height ratio, a HR of 1.80 (1.26–2.57). None of these measures were significantly associated with RC. Conclusions Obesity is positively associated with CC but not RC, and abdominal obesity exerts an independent effect. Reproductive factors had at best a weak effect on CC and RC. |
| Databáze: | OpenAIRE |
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