Oligomeric Cocoa Procyanidins Possess Enhanced Bioactivity Compared to Monomeric and Polymeric Cocoa Procyanidins for Preventing the Development of Obesity, Insulin Resistance, and Impaired Glucose Tolerance during High-Fat Feeding
| Autor: | Joseph R. Stevens, Liyun Ye, Laura E. Griffin, Katherine A. Thompson-Witrick, Katheryn M. Goodrich, Sean F. O'Keefe, Andrew P. Neilson, Melanie R. Dorenkott, Mostafa M. Ali, Matthew W. Hulver, Gabrielle Fundaro |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Flavonols medicine.medical_treatment Diet High-Fat Weight Gain Catechin Impaired glucose tolerance Eating Mice Structure-Activity Relationship Insulin resistance Tandem Mass Spectrometry Diabetes mellitus Glucose Intolerance medicine Animals Biflavonoids Proanthocyanidins Obesity Food science Chromatography High Pressure Liquid Cacao Chemistry Insulin Cocoa Extract food and beverages General Chemistry medicine.disease Mice Inbred C57BL Biochemistry Body Composition Fermentation Insulin Resistance medicine.symptom General Agricultural and Biological Sciences Weight gain |
| Zdroj: | Journal of Agricultural and Food Chemistry. 62:2216-2227 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf500333y |
| Popis: | There is interest in the potential of cocoa flavanols, including monomers and procyanidins, to prevent obesity and type-2 diabetes. Fermentation and processing of cocoa beans influence the qualitative and quantitative profiles of individual cocoa constituents. Little is known regarding how different cocoa flavanols contribute to inhibition of obesity and type-2 diabetes. The objective of this study was to compare the impacts of long-term dietary exposure to cocoa flavanol monomers, oligomers, and polymers on the effects of high-fat feeding. Mice were fed a high-fat diet supplemented with either a cocoa flavanol extract or a flavanol fraction enriched with monomeric, oligomeric, or polymeric procyanidins for 12 weeks. The oligomer-rich fraction proved to be most effective in preventing weight gain, fat mass, impaired glucose tolerance, and insulin resistance in this model. This is the first long-term feeding study to examine the relative activities of cocoa constituents on diet-induced obesity and insulin resistance. |
| Databáze: | OpenAIRE |
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