Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss
| Autor: | Marcel G. W. Dijkgraaf, Carla A. Wijbrandts, B L F van Eck-Smit, Paul P. Tak, Danielle M. Gerlag, Ruth Klaasen |
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| Přispěvatelé: | Clinical Immunology and Rheumatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Amsterdam Public Health, Epidemiology and Data Science, AII - Amsterdam institute for Infection and Immunity, ACS - Amsterdam Cardiovascular Sciences, Nuclear Medicine, Faculteit der Geneeskunde |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Time Factors Bone density Immunology Osteoporosis Urology Arthritis Antibodies Monoclonal Humanized Severity of Illness Index General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Rheumatology Bone Density medicine Adalimumab Immunology and Allergy Humans Prospective Studies Glucocorticoids Femoral neck Aged Bone mineral Lumbar Vertebrae business.industry Femur Neck Tumor Necrosis Factor-alpha Antibodies Monoclonal Clinical and Epidemiological Research Middle Aged medicine.disease musculoskeletal system Surgery Osteopenia medicine.anatomical_structure C-Reactive Protein Methotrexate Rheumatoid arthritis Antirheumatic Agents Prednisone Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Annals of the rheumatic diseases, 68(3), 373-376. BMJ Publishing Group Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases, 68(3), 373-376. BMJ Publishing Group |
| ISSN: | 0003-4967 |
| Popis: | Objective:To explore the effects of anti-tumour necrosis factor (TNF)α antibody therapy on bone mineral density (BMD) of the lumbar spine and femur neck in patients with rheumatoid arthritis (RA).Methods:A total of 50 patients with active RA (DAS28⩾3.2) who started adalimumab (40 mg subcutaneously/2 weeks) were included in an open label prospective study. All patients used stable methotrexate and were allowed to use prednisone (⩽10 mg/day). The BMD of the lumbar spine and femur neck was measured before and 1 year after start of treatment.Results:Disease activity at baseline (28-joint Disease Activity Score (DAS28)) and disease duration were inversely correlated with femoral neck BMD and lumbar spine BMD (pConclusion:In contrast to the progressive bone loss observed after conventional disease-modifying antirheumatic drug therapy, TNF blockade may result in an arrest of general bone loss. Consistent with previous observations, the data also suggest that the net effect of low-dose corticosteroids on BMD in RA may be beneficial, possibly resulting from their anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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