Influence of Ion Pairing Salts on the Transcorneal Permeability of Ionized Sulfonamides
| Autor: | Richard H. Buck, Curtis W. Conroy |
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| Rok vydání: | 1992 |
| Předmět: |
Anions
Inorganic chemistry In Vitro Techniques Permeability Cornea Benzolamide chemistry.chemical_compound Reaction rate constant Cations Carbonic anhydrase Animals Organic chemistry Pharmacology (medical) Ammonium Phosphonium Pharmacology Sulfonamides biology Cationic polymerization Biological Transport Ophthalmology chemistry Permeability (electromagnetism) Pairing biology.protein Rabbits |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 8:233-240 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.1992.8.233 |
| Popis: | The effects of cationic ammonium, phosphonium, and arsonium ion pairing salts as well as anionic organic and inorganic salts on the transcorneal permeability of ionized sulfonamide carbonic anhydrase inhibitors have been studied in the excised rabbit cornea. Benzolamide, thchloromethazolamide (TCM), MK-927, and quaternary ammonium sulfonamide (QAS) were examined. The enhancement in the first-order rate constants (kin) for the first compound in the presence of pairing salts was as much as 15 times the basal rate, with smaller increases seen with the remaining three drugs. Ion pairing salts may represent a means for enhancing the transcorneal permeability of highly ionized drugs. |
| Databáze: | OpenAIRE |
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