Single nucleotide polymorphism rs1800872 in the promoter region of the IL10 gene is associated with predisposition to chronic hepatitis C in Russian population
| Autor: | Galina V. Kochneva, A. G. Romaschenko, Andrey V. Barkhash, E. V. Chub |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Genotype Immunology Population Single-nucleotide polymorphism Microbiology Polymorphism Single Nucleotide Russia 03 medical and health sciences Flaviviridae Young Adult 0302 clinical medicine parasitic diseases medicine Encephalitis Viruses SNP Humans Genetic Predisposition to Disease education Promoter Regions Genetic Alleles Aged Genetics education.field_of_study biology Tick-borne encephalitis Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease biology.organism_classification Interleukin-10 030104 developmental biology Infectious Diseases Genetic marker 030211 gastroenterology & hepatology Female |
| Zdroj: | Microbes and infection. 20(3) |
| ISSN: | 1769-714X |
| Popis: | Previously, we studied an association of two IL28B gene single nucleotide polymorphisms (SNPs) and three IL10 gene SNPs with predisposition to tick-borne encephalitis in a Russian population. In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C. This SNP seems to be a common genetic marker of predisposition to two diseases caused by hepatitis C and tick-borne encephalitis viruses in Russian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect