Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion
| Autor: | Yoshiharu Sugamoto, Hiroshi Takase, Takeshi Yoshida, Toshiki Watanabe, Sunao Sugita, Manabu Mochizuki |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Interleukin 2
Leukemic Infiltration Pathology medicine.medical_specialty Letter genetic structures business.industry T cell medicine.disease eye diseases Sensory Systems Vitreous Floater Cellular and Molecular Neuroscience Ophthalmology medicine.anatomical_structure hemic and lymphatic diseases Intraocular fluid medicine sense organs Intraocular lymphoma IL-2 receptor business Uveitis medicine.drug |
| Zdroj: | British Journal of Ophthalmology. 90:1204-1206 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2006.092809 |
| Popis: | It has been reported that human T cell lymphotropic virus type I (HTLV-I) infection is related to a wide range of ocular disorders, such as intraocular lymphoma,1,2 uveitis,3 and cytomegalovirus (CNV) retinitis.4 The diagnosis of adult T cell leukaemia (ATL) cell infiltration in the eye is often difficult, even when characteristic ocular findings are present and cytological examinations of intraocular fluids are performed. It is well known that determination of patient serum interleukin 2 receptor alpha (sIL-2Rα) levels is critical in the evaluation of the clinical status of the disease.5 We report here a patient with systemic ATL who developed vitreous opacities and subretinal lesions and in whom vitreous measurement of the soluble form of sIL-2Rα provided information that could be used in making a diagnosis and in treating associated ocular disorders. A 69 year old man with a 2 year history of systemic ATL developed a sudden onset of decreased vision and vitreous floaters in the left eye. Funduscopic examination of the left eye revealed dense vitreous opacities and whitish retinal exudates along with superior vascular arcade (fig 1A). Based on the ocular manifestations and … |
| Databáze: | OpenAIRE |
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