Response of Plasmodium malariae infections to three different drugs; response to metachloridine, chloroguanide (paludrine), and intramuscular chloroquine
| Autor: | Sol B. McLendon, Martin D. Young |
|---|---|
| Rok vydání: | 1951 |
| Předmět: |
Sulfonamides
biology business.industry Sulfonamide (medicine) Chloroguanide Chloroquine Plasmodium malariae Quartan malaria Chloroquine diphosphate biology.organism_classification Virology Injections Intramuscular Malaria Proguanil Drugs response parasitic diseases medicine Humans business Metachloridine medicine.drug |
| Zdroj: | Journal of the American Medical Association. 147(9) |
| ISSN: | 0002-9955 |
| Popis: | In the search for more efficient drugs in the treatment of Plasmodium malariae, the causative agent of quartan malaria, tests were made with metachloridine, chloroguanide hydrochloride and intramuscular chloroquine. Metachloridine, a sulfonamide with the formula N1-(5-chloro-2-pyrimidyl) metanilamide, was found in a field study by Kenney and Brackett 1 (1947) to suppress natural infections of P. malariae. At the time the work reported here was started, the few scattered reports (Fairley, 2 Afridi, 3 Jafar, 4 Parekh and Boghani, 5 and Viswanathan and Baily 6 ) on the treatment of P. malariae with chloroguanide gave results ranging from satisfactory to unsatisfactory or inconclusive, the latter owing to the small number of cases or lack of adequate data. The action of chloroquine diphosphate given orally against our strain of P. malariae infections has been reported previously. 7 Later, Culwell and others 8 (1948) and Spicknall and others 9 (1949) found that chloroquine administered |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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