Dental mesenchymal stem cells and neuro-regeneration: a focus on spinal cord injury
| Autor: | Rosario Iemmolo, Ignazio Barbagallo, Valentina La Cognata, Gabriele Bonaventura, Sebastiano Cavallaro, Maria Luisa Barcellona, Salvatore Incontro, Erminio Costanzo, Rosalia Pellitteri |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cell therapy Human dental stem cells Mesenchymal stem cells Spinal cord injury Histology Cell- and Tissue-Based Therapy Regenerative medicine Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Tissue engineering Dental pulp stem cells Medicine Animals Humans Dental Pulp Spinal Cord Injuries Human dental stem cells mesenchymal stem cells cell therapy spinal cord injury business.industry Regeneration (biology) Mesenchymal stem cell Mesenchymal Stem Cells Cell Biology medicine.disease Nerve Regeneration 030104 developmental biology Stem cell business Neuroscience 030217 neurology & neurosurgery Adult stem cell |
| Zdroj: | Cell & tissue research (Internet) 379 (2020): 421–428. doi:10.1007/s00441-019-03109-4 info:cnr-pdr/source/autori:Gabriele Bonaventura; Salvatore Incontro; Rosario Iemmolo; Valentina La Cognata; Ignazio Barbagallo; Erminio Costanzo; Maria Luisa Barcellona; Rosalia Pellitteri; Sebastiano Cavallaro/titolo:Dental Mesenchymal Stem Cells and neuro-regeneration: a focus on Spinal Cord Injury/doi:10.1007%2Fs00441-019-03109-4/rivista:Cell & tissue research (Internet)/anno:2020/pagina_da:421/pagina_a:428/intervallo_pagine:421–428/volume:379 |
| ISSN: | 1432-0878 |
| DOI: | 10.1007/s00441-019-03109-4 |
| Popis: | Regenerative medicine is a branch of translational research, that aims to reestablish irreparably damaged tissues and organs by stimulating the body''s own repair mechanisms via the implantation of stem cells differentiated into specialized cell types. A rich source of adult stem cells is located inside the tooth and is represented by human dental pulp stem cells, or hDPSCs. These cells are characterized by a high proliferative rate, have self-renewal and multi-lineage differentiation properties, and are often used for tissue engineering and regenerative medicine. The present review will provide an overview of hDPSCs and related features with a special focus on their potential applications in regenerative medicine of the nervous system, such as, for example, after spinal cord injury. Recent advances in the identification and characterization of dental stem cells and in dental tissue -engineering strategies suggest that bioengineering approaches may successfully be used to regenerate districts of the Central Nervous System, previously considered irreparable. |
| Databáze: | OpenAIRE |
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