Ex Vivo Characterization of Canine Liver Tissue Viscoelasticity after High-Intensity Focused Ultrasound Ablation
| Autor: | Elisa E. Konofagou, Danial Shahmirzadi, Jiangang Chen, Gary Y. Hou |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science Acoustics and Ultrasonics medicine.medical_treatment Biophysics In Vitro Techniques Sensitivity and Specificity Article Viscoelasticity Shear modulus Dogs Hardness In vivo Elastic Modulus Image Interpretation Computer-Assisted medicine Animals Hepatectomy Radiology Nuclear Medicine and imaging Elasticity (economics) Radiological and Ultrasound Technology Viscosity business.industry Ultrasound Reproducibility of Results Ablation High-intensity focused ultrasound Liver Elasticity Imaging Techniques High-Intensity Focused Ultrasound Ablation Shear Strength business Ex vivo Biomedical engineering |
| Zdroj: | Ultrasound in Medicine & Biology. 40:341-350 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2013.09.016 |
| Popis: | The potential of elasticity imaging to detect high-intensity focused ultrasound (HIFU) lesions on the basis of their distinct biomechanical properties is promising.However, information on the quantitative mechanical properties of the tissue and the optimal intensity at which to determine the best contrast parameters is scarce. In this study, fresh canine livers were ablated using combinations of ISPTA intensities of 5.55, 7.16 and 9.07 kW/cm 2 and durations of 10 and 30 s ex vivo, resulting in six groups of ablated tissues. Biopsy samples were then interro- gated using dynamic shear mechanical testing within the range of 0.1-10 Hz to characterize the tissue's post- ablation viscoelastic properties. All mechanical parameters were found to be frequency dependent. Compared with unablated cases, all six groups of ablated tissues had statistically significant higher complex shear modulus and shear viscosity. However, among the ablated groups, both complex shear modulus and shear viscosity were found to monotonically increase in groups 1-4 (5.55 kW/cm 2 for 10 s, 7.16 kW/cm 2 for 10 s, 9.07 kW/cm 2 for 10 s, and 5.55 kW/cm 2 for 30 s, respectively), but to decrease in groups 5 and 6 (7.16 kW/cm 2 for 30 s, and 9.07 kW/cm 2 for 30 s, respectively). For groups 5 and 6, the temperature was expected to exceed the boiling point, and therefore, the decreased stiffening could be due to the compromised integrity of the tissue microstructure. Future studies will entail estimation tissue mechanical properties in vivo and perform real-time monitoring of tissue alterations during ablation. (E-mail: ek2191@columbia.edu) 2014 World Federation for Ultrasound in Medicine & Biology. |
| Databáze: | OpenAIRE |
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