Nucleophilic fluorination facilitated by a CsF–CaF2 packed bed reactor in continuous flow
| Autor: | Martin B. Johansen, Anders T. Lindhardt |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Packed bed
FLUORIDE SALTS Materials science 010405 organic chemistry Continuous flow Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials DRUG DISCOVERY Nucleophile Chemical engineering F BOND FORMATION CHEMISTRY Reagent Materials Chemistry Ceramics and Composites REAGENTS ALUMINA TRIFLUOROMETHYLATION ION |
| Zdroj: | Johansen, M B & Lindhardt, A T 2018, ' Nucleophilic fluorination facilitated by a CsF-CaF 2 packed bed reactor in continuous flow ', Chemical Communications, vol. 54, no. 7, pp. 825-828 . https://doi.org/10.1039/c7cc09035h |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations. |
| Databáze: | OpenAIRE |
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