Consequences of VGluT3 deficiency on learning and memory in mice
| Autor: | Magdalena Chmelova, Dóra Zelena, Daniela Jezova, Mano Aliczki, Csilla Lea Fazekas, Hanga Réka Horváth, Lucia Balagova, József Haller, Diána Balázsfi, Zoltan Balogh, Agnesa Puhova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Amino Acid Transport Systems Acidic education Morris water navigation task Experimental and Cognitive Psychology Significant learning Reversal Learning Motor Activity Discrimination Learning 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine Cognition Avoidance learning Avoidance Learning Medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Reinforcement Maze Learning Mice Knockout Working memory business.industry 05 social sciences Cognitive flexibility Flexibility (personality) Memory Short-Term Conditioning Operant business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Physiologybehavior. 212 |
| ISSN: | 1873-507X |
| Popis: | The aim of the present study was to test the hypothesis that vesicular glutamate transporter 3 (VGluT3) deficiency is associated with cognitive impairments. Male VGluT3 knockout (KO) and wild type (WT) mice were exposed to a behavioral test battery covering paradigms based on spontaneous exploratory behavior and reinforcement-based learning tests. Reversal learning was examined to test the cognitive flexibility. The VGluT3 KO mice clearly exhibited the ability to learn. The social recognition memory of KO mice was intact. The y-maze test revealed weaker working memory of VGluT3 KO mice. No significant learning impairments were noticed in operant conditioning or holeboard discrimination paradigm. In avoidance-based learning tests (Morris water maze and active avoidance), KO mice exhibited slightly slower learning process compared to WT mice, but not a complete learning impairment. In tests based on simple associations (operant conditioning, avoidance learning) an attenuation of cognitive flexibility was observed in KO mice. In conclusion, knocking out VGluT3 results in mild disturbances in working memory and learning flexibility. Apparently, this glutamate transporter is not a major player in learning and memory formation in general. Based on previous characteristics of VGluT3 KO mice we would have expected a stronger deficit. The observed hypolocomotion did not contribute to the mild cognitive disturbances herein reported, either. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect