Efficacy and safety of dofetilide in patients with atrial fibrillation and atrial flutter
| Autor: | Parag P. Patel, Soraya Samii, Sallie K. Young, Mario D. Gonzalez, Gerald V. Naccarelli, Javier E. Banchs, Erica Penny-Peterson, Deborah L. Wolbrette |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Dofetilide Torsades de pointes Electrocardiography Physiology (medical) Internal medicine Atrial Fibrillation Phenethylamines medicine Humans Sinus rhythm Aged Proarrhythmia Sulfonamides Chi-Square Distribution medicine.diagnostic_test business.industry Atrial fibrillation Middle Aged medicine.disease Treatment Outcome Atrial Flutter Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents Atrial flutter medicine.drug |
| Zdroj: | Journal of Interventional Cardiac Electrophysiology. 23:111-115 |
| ISSN: | 1572-8595 1383-875X |
| DOI: | 10.1007/s10840-008-9290-6 |
| Popis: | Dofetilide, an IKr blocker has been demonstrated to be effective in terminating persistent atrial fibrillation and flutter (AF/AFL), and in maintaining sinus rhythm after direct current cardioversion (CV). It is not known, however, whether pharmacological conversion with dofetilide predicts maintenance of sinus rhythm. In addition, there is limited information comparing the efficacy of dofetilide in persistent versus paroxysmal AF/AFL. Eighty consecutive patients with AF/AFL (51 persistent, 29 paroxysmal) admitted for initiation of dofetilide were studied. Termination of persistent AF/AFL occurred in 61% of patients while 39% required CV. After 21 ± 19 months of follow-up, 37% of patients with persistent AF/AFL were free of recurrence. Acute conversion with dofetilide did not predict long term efficacy. Dofetilide was more effective in maintaining sinus rhythm in patients with AFL (65%) than in those with AF (25%) (p |
| Databáze: | OpenAIRE |
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