The human microbiota is associated with cardiometabolic risk across the epidemiologic transition
| Autor: | Jack A. Gilbert, Louise Lie, Stephanie Kliethermes, Lara R. Dugas, Brian T. Layden, Danny Baghdan, Jacob Plange-Rhule, Neil Gottel, Estelle V. Lambert, Walter F. Riesen, Beatriz Penalver Bernabe, Wolfgang Korte, Pascal Bovet, Kweku Bedu-Addo, Na Fei, Amy Luke, Terrence Forrester |
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| Přispěvatelé: | Loor, Juan J |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Aging Epidemiology Physiology Blood Pressure Gut flora Cardiovascular Vascular Medicine Ghana Geographical Locations South Africa 0302 clinical medicine Risk Factors Medicine and Health Sciences Prevotella Uncategorized 2. Zero hunger 0303 health sciences Multidisciplinary biology Human microbiome Genomics Middle Aged Medical Microbiology Cardiovascular Diseases 030220 oncology & carcinogenesis Medicine Female Waist Circumference Research Article Adult Jamaica General Science & Technology Science Veillonella Microbial Genomics Microbiology 03 medical and health sciences Metabolic Diseases Clinical Research Genetics Humans Dental/Oral and Craniofacial Disease Feces 030304 developmental biology Nutrition Mouth Bacteria 030306 microbiology Prevention Gut Bacteria Lachnospiraceae Organisms Biology and Life Sciences Cardiovascular Diseases/epidemiology Cardiovascular Diseases/microbiology Gastrointestinal Microbiome Ghana/epidemiology Jamaica/epidemiology Metabolic Diseases/epidemiology Metabolic Diseases/microbiology Mouth/microbiology South Africa/epidemiology United States/epidemiology biology.organism_classification United States 030104 developmental biology Blood pressure Medical Risk Factors People and Places Africa North America Microbiome Lipoprotein |
| Zdroj: | PloS one, vol 14, iss 7 PloS one, vol. 14, no. 7, pp. e0215262 PLoS ONE, Vol 14, Iss 7, p e0215262 (2019) PLoS ONE |
| Popis: | Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 25-45, from Ghana, South Africa, Jamaica, and the United States (US). CM risk was classified using the CM risk cut-points for elevated waist circumference, elevated blood pressure and elevated fasted blood glucose, low high-density lipoprotein (HDL), and elevated triglycerides. Gut-associated bacterial alpha diversity negatively correlated with elevated blood pressure and elevated fasted blood glucose. Similarly, gut bacterial beta diversity was also significantly differentiated by waist circumference, blood pressure, triglyceridemia and HDL-cholesterolemia. Notably, differences in inter- and intra-personal gut microbial diversity were geographic-region specific. Participants meeting the cut-points for 3 out of the 5 CM risk factors were significantly more enriched with Lachnospiraceae, and were significantly depleted of Clostridiaceae, Peptostreptococcaceae, andPrevotella. The predicted relative proportions of the genes involved in the pathways for lipopolysaccharides (LPS) and butyrate synthesis were also significantly differentiated by the CM risk phenotype, whereby genes involved in the butyrate synthesis via lysine, glutarate and 4-aminobutyrate/succinate pathways and LPS synthesis pathway were enriched in participants with greater CM risk. Furthermore, inter-individual oral microbiota diversity was also significantly associated with the CM risk factors, and oral-associatedStreptococcus, Prevotella, andVeillonellawere enriched in participants with 3 out of the 5 CM risk factors. We demonstrate that in a diverse cohort of African-origin adults, CM risk is significantly associated with reduced microbial diversity, and the enrichment of specific bacterial taxa and predicted functional traits in both gut and oral environments. As well as providing new insights into the associations between the gut and oral microbiota and CM risk, this study also highlights the potential for novel therapeutic discoveries which target the oral and gut microbiota in CM risk. |
| Databáze: | OpenAIRE |
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