Heart Valve Abnormalities in Systemic Sclerosis Patients; A Multicenter Cohort Study and Review of the Literature
| Autor: | Domenico Sambataro, A. A. Russo, Giuseppe Ronsivalle, Michele Colaci, Gianluca Sambataro, Giuliana Guggino, Ylenia Dal Bosco, Lorenzo Malatino, C. Schinocca, Ilenia De Andres |
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| Přispěvatelé: | Colaci M., Schinocca C., Dal Bosco Y., Ronsivalle G., Guggino G., De Andres I., A. Russo S., Sambataro D., Sambataro G., Malatino L. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aortic valve
Adult Male medicine.medical_specialty Heart Valve Diseases Tricuspid stenosis Scleroderma Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Tricuspid Valve Insufficiency Mitral Internal medicine Medicine Humans Multicenter Studies as Topic cardiovascular diseases 030212 general & internal medicine Heart valve skin and connective tissue diseases Aged 030203 arthritis & rheumatology Scleroderma Systemic integumentary system business.industry Systemic Mitral Valve Insufficiency Middle Aged medicine.disease Valvular disease Heart Valves Stenosis medicine.anatomical_structure Pulmonary valve cardiovascular system Cardiology Systemic sclerosis Female business Tricuspid Cohort study |
| Popis: | Background Systemic sclerosis (SSc) is a chronic autoimmune disease that is characterized by vasculopathy and fibrosis of the skin and visceral organs. Heart valve diseases are poorly described and generally not considered typical of SSc. We aimed to describe valvular abnormalities in a multicenter cohort of SSc patients and to investigate their correlation with SSc features. Methods We recruited 118 consecutive SSc patients (male/female, 14/104; mean age, 55.2 ± 12.1 years) in 3 rheumatology centers in Sicily, Italy, from January to October 2019. Results Mitral and tricuspid valve insufficiency was found in 85% and 91% of patients, respectively; regurgitations were generally mild and never severe. Mitral stenosis was rare (2%), and tricuspid stenosis was not observed. Sclerosis and calcification were present in 30% of mitral valves and in only 4% of tricuspid valves. The aortic valve was affected in 25% of cases, and it generally presented as regurgitation or sclerosis, whereas stenosis was rare (3%). Finally, 11% of SSc patients showed regurgitation of the pulmonary valve. No specific associations between SSc features and valve alterations were found. Conclusions Valvular diseases are frequently observed in SSc patients, with a predominant pattern of valvular regurgitations. Therefore, echocardiography should be routinely performed during SSc patient follow-up, considering the potential influence of additional cardiac involvement in the prognosis of these patients. |
| Databáze: | OpenAIRE |
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