Primary cutaneous ganglioneuroma: anatomico-clinical study of 4 cases with focus on Merkel cells
| Autor: | Bernard Cribier, David Romero-Pérez, Isabelle Penchet, Claire Lecointre, Marie-Hélène Jegou |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Seborrheic keratosis medicine.medical_specialty Pathology Skin Neoplasms Histology Dermatology Merkel Cells Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Ganglioneuroma music Aged Cutaneous Ganglioneuroma music.instrument integumentary system Epidermis (botany) business.industry Middle Aged Hyperplasia medicine.disease Follicular hyperplasia medicine.anatomical_structure 030220 oncology & carcinogenesis Female Histopathology business Merkel cell |
| Zdroj: | Journal of Cutaneous Pathology. 45:403-411 |
| ISSN: | 0303-6987 |
| DOI: | 10.1111/cup.13144 |
| Popis: | Cutaneous ganglioneuromas (CGNs) are exceptional. We aim to describe the anatomico-clinical profile of primary CGN and report 4 cases. Patients were 2 men and 2 women aged 53 to 76 years, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, that is, epidermal nevus (1 case) or seborrheic keratosis (3 cases). Histopathology showed ganglion cells within a proliferation of Schwann cells. The epidermis was acanthotic, associated with sebaceous induction in 2 cases, with follicular hyperplasia as in fibroepithelial tumors (1 case) or with tricholemmoma (2 cases). Cytokeratin-20 immunostaining showed Merkel cells in the epidermis. A higher density of Merkel cells was observed in BerEP4+ follicular structures. Along with 16 published cases, our study indicates that a nodule associated with seborrheic keratosis on the back may represent a CGN, a complex mesenchymal and epidermal/follicular lesion of neuroectodermal lineage, associating neuronal proliferation and Merkel cell hyperplasia with follicular induction. |
| Databáze: | OpenAIRE |
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