Injectable and responsively degradable hydrogel for personalized photothermal therapy
| Autor: | Yiyun Cheng, Xinyu Wang, Changping Wang, Jian Luo, Qiang Zhang, Kunyu Dong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Biocompatibility Biophysics Cancer therapy Metal Nanoparticles Bioengineering macromolecular substances 02 engineering and technology Injections Intralesional 010402 general chemistry complex mixtures 01 natural sciences Hydrogel Polyethylene Glycol Dimethacrylate Biomaterials In vivo Absorbable Implants Humans Tumor growth Non invasive technology industry and agriculture Hyperthermia Induced Neoplasms Experimental Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology 0104 chemical sciences Increased risk Treatment Outcome Mechanics of Materials Self-healing hydrogels Ceramics and Composites MCF-7 Cells 0210 nano-technology Biomedical engineering |
| Zdroj: | Biomaterials. 104 |
| ISSN: | 1878-5905 |
| Popis: | Near infrared-absorbing hydrogels are used for the repeated photothermal treatments of cancer. However, a long-term retention of hydrogel in the body leads to increased risk of toxicity. Here we developed an injectable and on-demand degradable hydrogel to conduct the repeated photothermal therapies (PTTs). Alginate-calcium hydrogel immobilized dendrimer-encapsulated platinum nanoparticles (DEPts) in its matrix represented excellent biocompatibility, and was degraded upon injecting chelates. Results from the in vivo studies reveal that the hydrogel/DEPts-mediated repeated PTTs suppressed tumor growth efficiently, and the hydrogel was degraded on-demand to allow renal secretion of DEPts out of the body. Furthermore, coating hydrogel/DEPts on the tumor instead of intratumoral injection could still ablate tumor efficiently. Our investigation provides a smart and safe hydrogel for photothermal cancer therapy. |
| Databáze: | OpenAIRE |
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